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Comparative Molecular Dynamics Simulations of HIV-1 Integrase and the T66I/M154I Mutant: Binding Modes and Drug Resistance to a Diketo Acid Inhibitor

机译：HIV-1整合酶和T66I / m154I突变体的比较分子动力学模拟：结合模式和对二酮酸抑制剂的耐药性

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Ro Brigo; Keun Woo Lee; Federico Fogolari; Gabriela Iurcu Mustata; James M. Briggs;
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1. Comparative molecular dynamics simulations of HIV-1 integrase and the T66I/M154I mutant: binding modes and drug resistance to a diketo acid inhibitor. [J] . Brigo A, Lee KW, Fogolari F, Proteins: Structure, Function, and Genetics . 2005,第4期

机译：HIV-1整合酶和T66I / M154I突变体的比较分子动力学模拟：对二酮酸抑制剂的结合模式和耐药性。
2. Potent Inhibitors of HIV-1 Integrase Display a Two-Step, Slow-Binding Inhibition Mechanism Which Is Absent in a Drug-Resistant T66I/M154I Mutant [J] . Edward P. Garvey Benjamin Schwartz Margaret J. Gartland Scott Lang Wendy Halsey Ganesh Sathe H. Luke Carter III. and Kurt L. Weaver Biochemistry . 2009,第7期

机译：HIV-1整合酶的有效抑制剂表现出两步，缓慢结合的抑制机制，这种机制在抗药性T66I / M154I突变体中不存在
3. Binding modes of diketo-acid inhibitors of HIV-1 integrase: A comparative molecular dynamics simulation study [J] . Huang M., Grant G.H., Richards W.G. Journal of molecular graphics & modelling . 2011,第7期

机译：HIV-1整合酶的二酮酸抑制剂的结合模式：比较分子动力学模拟研究
4. Comparative study of Differential Evolutionary-Binary Particle Swarm Optimization (DE-BPSO) algorithm as a feature selection technique with different linear regression models for analysis of HIV-1 Integrase Inhibition features of Aryl β-Diketo Acids [C] . Falguni Thakor, Ahmad Reza Hadaegh, Xiaoyu Zhang International Conference on Bioinformatics and Computational Biology . 2017

机译：差分进化二元粒子群优化（DE-BPSO）算法作为具有不同线性回归模型的特征选择技术的对比研究分析芳基β-Diketo酸的HIV-1整合酶抑制特征
5. Design and synthesis of molecular probes to modulate cell membrane permeation: I. Design, synthesis, and biological evaluation of novel chicoric acid analogues as inhibitors of HIV-1 integrase. II. Design, synthesis, and biological evaluation of novel estradiol analogues targeting the membrane estrogen receptor. [D] . Charvat, Trevor Thomas. 2004

机译：设计和合成的分子探针，可调节细胞膜的渗透性：I.设计，合成和生物评价作为抗HIV-1整合酶抑制剂的新型菊苣酸类似物。二。针对膜雌激素受体的新型雌二醇类似物的设计，合成和生物学评估。
6. Binding modes of diketo-acid inhibitors of HIV-1 integrase: A comparative molecular dynamics simulation study [O] . Meilan Huang, Guy H. Grant, W. Graham Richards -1

机译：HIV-1整合酶的二酮酸抑制剂的结合模式：分子动力学比较模拟研究
7. Binding modes of diketo-acid inhibitors of HIV-1 integrase: a comparative molecular dynamics simulation study. [O] . Huang, Meilan, Grant, Guy H., Richards, W. Graham 2011

机译：HIV-1整合酶的二酮酸抑制剂的结合模式：分子动力学比较研究。

Comparative Molecular Dynamics Simulations of HIV-1 Integrase and the T66I/M154I Mutant: Binding Modes and Drug Resistance to a Diketo Acid Inhibitor

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